Oxatomide in the treatment of pruritus senilis. A double-blind placebo-controlled trial. Dupont C, de Maubeuge J, Kotlar W, Lays Y, Masson M. Complete suppression or marked improvement of the complaints was experienced by 79% of the patients given oxatomide and by 31% of the control patients. Pruritus Senilis - Download as PDF File .pdf), Text File .txt) or read online. THE TREATMENT OF PRURITUS SENILIS. DOI:(00) · THE TREATMENT OF PRURITUS SENILIS.
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Pruritus | Primary Care Dermatology Society | UK
Emotional distress plays an important role in the development and control of this disturbing symptom. Unless pruritus pruritus senilis relieved the patient may become exhausted from lack of sleep.
Pruritus senilis, soothing ointments or lotions, sodium bicarbonate baths, and sometimes tranquilizing drugs are used in the relief of pruritus. Pruritus senilis it is a symptom of some other disorder, complete cure of pruritus depends on control of the primary illness. Ageing is a decline in the normal functioning of all organ systems, including the skin.
Ageing is a biological reality, a complex process due to the accumulation of molecular damage over time The consequences are declines in healing capacity, immune responsiveness and capacity to repair DNA. The decline in the normal physiology of the skin, age-related changes in cutaneous nerve fibres, polypharmacy, and other medical comorbidities contribute to the high rate of pruritus in elderly people Skin changes may contribute to decreased skin surface lipids and clearance pruritus senilis trans-epidermal materials from the dermis.
Sweat and sebum production are reduced and barrier repair is diminished Xerosis pruritus senilis elderly people arises in part pruritus senilis to age-dependent physiological changes in the ability of the skin to produce and retain moisture 30, 47but it is not a normal part of ageing Older adults lack fatty acids in the skin that augment hydration, which contributes to xerosis.
The stratum corneum consists of corneal cells and intercellular lipids, which form a watertight configuration responsible for the skin barrier. This barrier is delicate, and damage from scratching, degreasing by detergents and dermatoses can change the trans-epidermal loss of body fluids that maintain homeostasis of the skin Stratum corneum lipids play a predominant role in maintaining the water pruritus senilis of the skin Pruritus senilis patients with senile pruritus have clinically drier skin than age- and sex-matched control subjects.
This xerosis is caused by a chronic skin hydration problem. Aquaphorin-3 AQP3a membrane channel, allows the passage of glycerol and water.
AQP3 gene expression is significantly reduced in the skin of people aged 60 years and over The epidermal barrier function is linked to skin hydration. The ageing process tends to increase epidermal surface pH, which leads to reduced activity of lipid-forming enzymes, and, pruritus senilis, a decrease in the production of ceramide in the stratum corneum.
The decrease in the lipid formation capacity and fluid loss affect the epidermal barrier function and could contribute to senile pruritus.
Changes in the stratum corneum and altered skin surface contour parameters suggest that senile pruritus could be associated with an acquired abnormality of keratinization. An analysis of intracorneal cohesion shows an increase that can be found in other disorders, including psoriasis, ichthyosis and atopic eczema The impulse travels to the ipsilateral dorsal root ganglia before crossing to the contralateral anterolateral spinothalamic tract and being transmitted to the thalamus and internal capsule and finishing in the sensory cortex 6.
An analysis of these fibres in people with pruritus suggested that there was pruritus senilis reduction in inhibition in the spinal cord.
Pruritus senilis | definition of pruritus senilis by Medical dictionary
Therefore, pruritus could be caused by a probable abnormality in spinal interneurons In elderly people, pruritus may be more frequently favoured by pruritus senilis reduction in the itch threshold to other stimuli.
A deficiency in skin hydration may be responsible for a reduction in this threshold because emollients can allow better accuracy of sensory perception in elderly people Kaposi was the first to propose a neural mechanism 6. A hypothesis to explain senile pruritus pruritus senilis a pruritus senilis change in peripheral nerve endings may be attributable to age It is probably a subclinical neuropathy 6.