Mycophenolate mofetil is the 2-morpholinoethyl ester of mycophenolic acid (MPA), an immunosuppressive agent, inosine monophosphate dehydrogenase. Mycophenolate belongs to a group of medicines known as immunosuppressive agents. It is used with other medicines to lower the body's natural immunity in. Mycophenolic acid, also called mycophenolate, is an immunosuppressant drug used to prevent rejection in organ transplantation. It was initially marketed as the prodrug mycophenolate mofetil (MMF) to Pregnancy category: AU: D; US: D (Evidence of.
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Breast feeding Manufacturer advises avoid—present in milk in animal studies.
Renal impairment No data mycophenolate mofetilo in cardiac or hepatic transplant patients with renal impairment. Mycophenolic mycophenolate mofetilo is important because of its selective effects on the immune system.
It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells.
It mycophenolate mofetilo may inhibit recruitment of leukocytes to inflammatory sites. Intravenous IV administration of mycophenolate mofetil is also commonly associated with thrombophlebitis and thrombosis.
- Mycophenolate mofetil and its mechanisms of action.
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Infrequent mycophenolate mofetilo effects 0. Mycophenolate mofetilo and Drug Administration FDA has issued an alert that patients on mycophenolate mofetil and mycophenolic acid are at increased risk of opportunistic infectionssuch as activation of latent viral infections, including shinglesother herpes infections, cytomegalovirusand BK virus associated nephropathy.
In addition the FDA mycophenolate mofetilo investigating 16 patients that developed a rare neurological mycophenolate mofetilo while taking the drug. This is a viral infection known as progressive multifocal leukoencephalopathy ; it attacks the brain and is usually fatal. Other changes in blood chemistry such as hypomagnesemiahypocalcemiahyperkalemiaand an increase in blood urea nitrogen BUN can occur.
Mycophenolate mofetil and its mechanisms of action. This is the rate-limiting enzyme in de novo synthesis of guanosine nucleotides.
T- and B-lymphocytes are more dependent on this pathway than other cell types are.