Preparation of Hertwig's epithelial root sheath (HERS). HERS formation can be seen in histologic sections of 7 days postnatal mice first. To accomplish this goal, we have focused our efforts in understanding the role of Hertwig?s epithelial root sheath (HERS) in this process. Towards this end. At the end edge of the tooth crown, inner and outer enamel epithelia form Hertwig's epithelial root sheath (HERS). HERS extends along with.
|Published:||12 April 2014|
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These studies suggest that the acellular and cellular cementum are synthesized by two different types of cells, the first one by HERS-derived cementoblasts and the later by neural crest-derived cementoblasts.
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An inflexible joint is formed between the tooth and the bone at the apical end of the tooth where the epithelium remains open. In amphibians and hertwigs epithelial root sheath reptiles a continuous root sheath or HERS is formed without fragmentation of the epithelium.
Using developmental, evolutionary, and cell biological approaches we have therefore performed a careful analysis of the role of Hertwigs epithelial root sheath in root formation and compared our data with clinical findings.
Our developmental studies revealed HERS as a transient structure assembled in the early period of root formation and elongation and subsequently fenestrated and reduced to epithelial rests of Malassez ERM.
Cementogenesis: Role of Hertwig's Epithelial Root Sheath - Margarita Zeichner-David
The data generated in this study will provide much needed information related to the process of root formation and the regulatory factors involved in this process.
This data is of great health relevance to understand genetic defects hertwigs epithelial root sheath in root agenesis which result in premature tooth loss.
Additionally, understanding root and periodontium development is critical to establish genetical and tissue engineering therapies for periodontium regeneration.